The spacewalk – which Al Neyadi will do with NASA Flight Engineer Stephen Bowen - is set to last about six and a half hours.
Al Neyadi is the second Emirati to travel into space, following on from Hazza Al Mansouri's eight-day stay on the ISS in September 2019.
Nasa has set a new launch date for the SpaceX rocket carrying Emirati astronaut Sultan Al Neyadi after the blast-off was postponed on February 27.
The mission will make the UAE the 11th country to send astronauts on a long-duration mission to the International Space Station.
The UAE astronaut will serve as a mission specialist on the SpaceX Crew-6 mission.
The Emirati astronaut will join NASA’s Stephen Bowen and Warren Hoburg alongside Russian cosmonaut Andrei Fedyaev.
The companies aim to open space to a broad user base, providing data to help solve global-scale problems.