The four-person Ax-2 crew will spend 10 days at the station conducting research and educational outreach activities.
ISS
Hazzaa AlMansoori, the Expedition 69 increment lead, joined Al Neyadi from the NASA ground station in Houston.
The spacewalk – which Al Neyadi will do with NASA Flight Engineer Stephen Bowen - is set to last about six and a half hours.
Al Neyadi is the second Emirati to travel into space, following on from Hazza Al Mansouri's eight-day stay on the ISS in September 2019.
Nasa has set a new launch date for the SpaceX rocket carrying Emirati astronaut Sultan Al Neyadi after the blast-off was postponed on February 27.
The mission will make the UAE the 11th country to send astronauts on a long-duration mission to the International Space Station.
The UAE astronaut will serve as a mission specialist on the SpaceX Crew-6 mission.